Epidemics, Slavery, Massacres, and Indigenous Resistance 1492-1599
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1493+
Disease decimates island populations
Post-Columbus contact, measles, smallpox, scarlet fever, and other diseases kill Natives by the hundreds of...Read More
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1500+
Arawak resistance and mass suicides
Facing extermination, the Arawak organize and attempt to fight back against the Spaniards. Overwhelmed by...Read More
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1513
Calusa of Florida drive Ponce de Leon away
Ponce de Leon accompanies Columbus on his second voyage and by the time they arrive...Read More
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1520
Guarocuya leads 14-year Arawak rebellion and resistance
On Hispaniola, Guarocuya, an Arawak resistance fighter, is eventually granted land by the Spanish without...Read More
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1521
Calusa chief outwits and kills Ponce de Leon
A Calusa chief tricks Ponce de Leon into building a settlement, only to attack it...Read More
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1522
Native slave rebellion in Hispaniola
A large-scale Native slave rebellion takes place against Spaniards.
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1528
Timucua of Florida drive Spanish invaders away
The Timucua drive off 400 Spanish settlers who attempt to land in Tampa Bay to...Read More
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1531
Yaqui of northern Mexico drive away Spanish slave traders
Nuno de Guzman seeks Native slaves in northern Mexico, but the Yaqui attack and drive...Read More
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1537
Native slaves in Hispaniola organize another rebellion against Spanish slave owners
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1539
De Soto, in quest for slaves and gold, is driven from southeastern tribal lands
Timucua, Appalachia, Coosa, Mobile, Natchez, Tonkawa, Choctaw, and other southeastern tribal groups fight de Soto’s...Read More
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1540
Mississippian woman chief of Cofitachequi outwits de Soto
While de Soto is among the Apalachee Indians in Florida, he hears of a kingdom...Read More
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1542
De Soto dies/is killed?
Textbooks note that de Soto suddenly becomes ill and dies. However, Choctaw and Chickasaw tribal...Read More
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1566
Calusa refuse forced conversion to Christianity (southwest Florida)
Already weakened by disease, the Calusa allow a Jesuit missionary into their territory but refuse...Read More
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1597
Guale Indians rebel (Georgia)
The Guale off of the Georgia coast rebel against the Spanish mission and encomienda system.