U.S. President Ulysses S. Grant launches a reorganization of the Indian Health Service and a relocation program to move tribes onto reservations and calls for the replacement of government officials on reservations with missionaries nominated by churches assigned to reservation regions. Grant proposes that these new agents can convert Natives on reservations to Christianity. Many tribes refuse and ignore relocation orders that force them onto undesirable, small land parcels. Enforcement of the reservation policy also requires that the U.S. Army restrict movements off the reservation, virtually imprisoning tribal members. As tribes resist, the U.S. Army pursuit to capture and remove tribes onto reservations takes off and leads to several violent standoffs, battles, and massacres. A well-known resistance effort includes the Battle of Little Bighorn. (https://en.wikipedia.org/wiki/Indian_reservation)